Where and when: Room W2303, Tuesday, 2/8, 12:15 PM
(and apologies up front - I will just be getting back from out of town and probably won't be able to make it)
Mandy Wilkinson of the Evans lab will be presenting two papers related to a certain step of fertilization, sperm interaction with the zona pellucida. (This is sort of a smackdown between genetic approaches and structural biology!)
Gamete recognition in mice depends on the cleavage status of an egg's zona pellucida protein
Science 329: 216-219
Gahlay et al. - from Jurrien Dean's group at NIDDK
Insights into egg coat assembly and sperm-egg interaction from the X-ray structure of full-length ZP3
Cell 143: 404-415
Han et al. - from Luca Jovine's group at the Karolinka Institute
Link to the structure
FYI - Perspectives articles related to these papers:
Mechanisms of sperm-egg interactions: Between sugars and broken bonds
Science Signaling 3:pe35
Egg's ZP3 structure speaks volumes
Cell 143: 337-338
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