Matt Beattie of the Zirkin lab helps us kick off our 2011 meetings (thanks, Matt!).
We'll meet at 12:15, Tuesday, Jan. 25, in Room E6519.
Matt will be presenting:
ROS inhibit the expression of testicular steroidogenic enzyme genes via the suppression of Nur77 transactivation.
Lee et al.
Free Radical Biology and Medicine, 2009, 47: 1591-1600
As Matt comments about this paper:
"I picked this paper because it is, well it's right in my field of study. This paper wants to establish a basis (via signalling and transcriptional regulation) for steroidogenic aging. While the "cause" of aging is still hotly debated, many groups are trying to establish an aging profile in both constantly dividing and terminally differentiated (or very low turnover) cells. The Leydig cell provides a great example of an aging terminally differentiated cell and allows us to study various aspects of the aging cell while measuring it's capacity to make steroids as a marker for their function."
Subscribe to:
Post Comments (Atom)
No comments:
Post a Comment