- When: Tuesday, Feb. 7, 12:15 PM
- Where: Room E6519, BSPH
A big thank-you to Hyo Lee (from my lab), who I roped in to starting off our journal club for this academic term. She'll be presenting:
Rhythmic actomyosin-driven contractions induced by sperm entry predict mammalian embryo viability
Nature Communications* 2011, 2:417 (Nat Commun is the Nature Publishing Group's new open access journal, another in the mushroom field of open access journals to pop up in the last year or so ... if you're losing count, so am I!)
Ajduk A, Ilozue T, Windsor S, Yu Y, Seres KB, Bomphrey RJ, Tom BD, Swann K, Thomas A, Graham CF, Zernicka-Goetz M. [lab website -- cool pics!]
The paper has some nice imaging of mouse embryos, revealing cellular events that were known to occur in other early embryos. (C. elegans embryos being especially famous for their cytoplasmic flows, and also are a model for events similar to those that Hyo is interested in in her project.) The authors of this paper also try to make the claim that characteristics of these flows will predict what embryos will produce live births -- something that the Assisted Reproductive Technology world would be quite interested in! But see what you think of the data ...
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