- When: Tuesday, Nov. 8, 12:15 PM
- Where: Room E6519, BSPH
Lauren Matthews of the Evans lab will be presenting two related papers:
Postfertilization autophagy of Sperm Organelles Prevents Paternal Mitochondrial DNA Transmission
Rawi et al., Science, published online October 27
Degradation of Paternal Mitochondria by Fertilization-triggered autophagy in C. elegans embryos
Sato and Sato, Science, published online October 27
Her comments:
"These papers caught my eye because they address an interesting reproductive biology question: are paternal mitochondria selectively eliminated after fertilization and if so, how does this occur? The authors demonstrate that paternal mitochondria are selectively eliminated from the early C. elegans embryo by autophagy in order to ensure maternal inheritance of mtDNA. A 2008 paper in Science showed that autophagy is upregulated after fertilization and is essential for early development of mouse embryos. It will be interesting to see if this mechanism for selective elimination of paternal mitochondria is conserved in mammals."
Hello,
ReplyDeleteThis is the perfect blog for anyone who wants to know about this topic. Autophagy is an essential process depending on the organism and the stress conditions. It can help kill cancer cells, which has recently been defined at the molecular level and is the cellular response to nutrient...
Apoptosis