When and where: Tuesday, May 17, 12:15 PM, Room E6519
Dolly of the Wright lab will be presenting:
Sin3a Is Required by Sertoli Cells to Establish a Niche for Undifferentiated Spermatogonia, Germ Cell Tumors, and Spermatid Elongation
Stem Cells (2010), 28:1424-1434
Payne, Gallagher, Foreman, Dannenberg, Depinho, and Braun
Dolly says, "I choose this paper because of its focus on Sertoli cells, an area that I am not too familiar with but most interested in further exploring.* The authors were interested in studying how the regulation of Sertoli cell chromatin is affected during fetal and juvenile periods of testis development and how it influences the establishment of the germ stem cell niche -- especially since Sertoli cells are sensitive to epigenetic alternation and play a role in the maintenance and formation of undifferentiated spermatogonia."
* Blog keeper's comment: Hey, good for you, Dolly!
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