When and where: Room W2303, Tuesday, April 12, 12:15 PM
Shiying Jin of the Zirkin lab will present:
Protein tyrosine kinase WEE1B is essential for metaphase II exit in mouse oocytes
Oh JS, Susor A, and Conti M [Marco Conti's UCSF webpage]
Science 2011, ePub ahead of print (DOI: 10.1126/science.1199211)
This paper presents the interesting finding that (as the abstract states), "... exit from metaphase requires not only a proteolytic degradation of cyclin B, but also the inhibitory phosphorylation of Cdc2 by Wee1B," as well as reveals an additional role for Calcium/Calmodulin-dependent kinase II (CaMKII) in the egg-to-embryo transition. This work also extends what we know about WEE1B functions in oocytes, complementing previous work of the Conti lab on the role of WEE1B in prophase I arrest (Curr Biol, 15:1670).
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