Becca from the Matunis lab will be presenting (12:30 in W2303 in the SPH).Two-step oligoclonal development of male germ cells; PNAS 2009, 106:175-180
Ueno, Turnbull, and Weissman
Weissman lab profile here
Hot off the presses (FYI) - a profile on Weissman in the brand new issue of JCB
Becca's comments on this paper choice -
"This paper uses tetrachimeric mice to mark and study the development of the male germline and finds that the entire lineage is derived from a mere 4 cells. One of my projects is to characterize the primodial germ cell (PGC) to germline stem cell (GSC) transition in Drosophila embryos. It has long been known that, in Drosophila, the number of PGCs initially incorporated into the gonad is greater than the number of GSCs, suggesting that some sort of selection process occurs. This paper suggests that there are parallel themes in mammals, where germ cells that actually contribute to adult spermatogenesis also arise from a smaller, perhaps select few, cells within a pool of potential founder cells."
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