Chris from the Matunis lab will be leading a discussion of:
Plzf is required in adult male germ cells for stem cell self-renewal (Buass et al., Nature Genetics, 2004)
and a bit on the follow-up paper:
Histone lysine trimethylation exhibits a distinct perinuclear distribution in in Plzf-expressing spermatogonia (Payne and Braun, Dev. Biol. 2006)
"I chose this paper because it is one of very few reports that I am aware of demonstrating the role of an epigenetic regulator in the maintenance of mammalian germline stem cells. Although much work has been done regarding epigenetic modifications in differentiated germ cells, less is known about the role of epigenetic and chromatin modification in germline stem cell function. In our lab I am study the role of a chromatin remodeling complex, NURF, in the maintenance of Drosophila testis stem cells. Specifically, we are interested in understanding how chromatin remodeling factors contribute to the maintenance of stem cells within their endogenous niche including the role of the epigenetic state of a stem cell in its ability to interpret niche signals."
No comments:
Post a Comment