Mouse differentiating spermatogonia can generate germinal stem cells in vivo
Barroca et al., Nature Cell Biology 11, 190 - 196 (2008)
Becca from the Matunis lab will be presenting. Here's what she says about the paper:
"Basically I chose this paper because it demonstrates that differentiating spermatogonia have the potential to reconstitute spermatogensis in gamma-irradiated mouse testes. It suggests that in the permissive microenvironment and with the appropriate cellular factors, differentiating spermatogonia can be re-programmed into germline stem cells.
This paper is directly relevant to my research as I am trying to understand the mechanism of dedifferentiation using Drosophila spermatogensis as a model system. Our system is especially useful because we know the precise location of the stem cell niche and have cellular markers that distinguish germline stem cells from their immediate daughters. We are also able to genetically manipulate the niche, and recently, we have developed methods to image the niche live in order to observe the cellular rearrangements that occur during dedifferentiation."
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