When and where:
Room W2303, Tuesday, Nov. 30, 12:15.
Hyo from the Evans lab will be presenting:
Granulosa Cell Ligand NPPC and Its Receptor NPR2 Maintain Meiotic Arrest in Mouse Oocytes
Zhang M, Su YQ, Sugiura K, Xia G, Eppig JJ [Eppig Jax website]
Science, 2010, 330: 366-9
Hyo's comment on her paper choice:
"Mammalian oocytes are arrested at prophase I until signals allow for their meiotic maturation. This paper proposes a mechanism by which the arrest is maintained. The paper is especially interesting to me as I have observed differences in spindle morphology and cortical mechanics in mouse eggs matured in vivo vs. in vitro. If time permits, I will share some of my own findings!"
Wednesday, December 8, 2010
Wednesday, November 24, 2010
Nov. 30, 2010 journal club
When and where:
Room E6519, Tuesday, Nov. 30, 12:15.
Rachel from the Matunis lab will be presenting:
Functional hierarchy and reversibility within the murine spermatogenic stem cell compartment
Nakagawa et al.
Science, 2010, 328:62-67
Rachel's comment on this paper:
"I picked this one because it beautifully illustrates that the mouse germline is not simply a linear path of cells that is fed by stem cells balancing self renewal and differentiation. Spermatogonia on their way down a path of differentiation can revert toward a more undifferentiated state to keep the germline in balance. Of course we already had hints of this from the awesome model system that is Drosophila but it is always reassuring to find that observations in model organisms hold true up the evolutionary ladder. Previously, in a paper that Becca did for RBJC, (Barroca et al.) it was shown that spermatogonia (no stem cells) could be transplanted into gamma irradiated mice with no functional germline niche, and the transplanted cells could reconstitute the niche. This suggested that these cells were capable of dedifferentiating but this paper is the first to make this observation in vivo in a wildtype (i.e., non-transplanted) situation."
Other papers that Rachel notes are of interest:
Spralding and Fan, "Counterfeiting the family jewels," Cell Stem Cell, 2010, 6:405-406.
Klein et al., "Mouse germ line stem cells undergo rapid and stochastic turnover," Cell Stem Cell, 2010, 7:214-224.
Room E6519, Tuesday, Nov. 30, 12:15.
Rachel from the Matunis lab will be presenting:
Functional hierarchy and reversibility within the murine spermatogenic stem cell compartment
Nakagawa et al.
Science, 2010, 328:62-67
Rachel's comment on this paper:
"I picked this one because it beautifully illustrates that the mouse germline is not simply a linear path of cells that is fed by stem cells balancing self renewal and differentiation. Spermatogonia on their way down a path of differentiation can revert toward a more undifferentiated state to keep the germline in balance. Of course we already had hints of this from the awesome model system that is Drosophila but it is always reassuring to find that observations in model organisms hold true up the evolutionary ladder. Previously, in a paper that Becca did for RBJC, (Barroca et al.) it was shown that spermatogonia (no stem cells) could be transplanted into gamma irradiated mice with no functional germline niche, and the transplanted cells could reconstitute the niche. This suggested that these cells were capable of dedifferentiating but this paper is the first to make this observation in vivo in a wildtype (i.e., non-transplanted) situation."
Other papers that Rachel notes are of interest:
Spralding and Fan, "Counterfeiting the family jewels," Cell Stem Cell, 2010, 6:405-406.
Klein et al., "Mouse germ line stem cells undergo rapid and stochastic turnover," Cell Stem Cell, 2010, 7:214-224.
Monday, November 1, 2010
Nov. 16, 2010 journal club
When and where:
Room W2303, Tuesday, Nov. 16, 12:15.
(Note the different room -- we got bumped from E6519 for this week, and will be in the room on the 2nd floor that we used most of last year.)
Newly-defended Leesa (that's DR. LaFever to you!) from the Drummond-Barbosa lab will be presenting:
TGF-β and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance
Luo, Kleeman, Ashraf, Shaw, and Murphy
Cell, 2010, 143:299-312
A nice complement to the Oct. 19 journal club, and recently highlighted in the NYT as well!
Room W2303, Tuesday, Nov. 16, 12:15.
(Note the different room -- we got bumped from E6519 for this week, and will be in the room on the 2nd floor that we used most of last year.)
Newly-defended Leesa (that's DR. LaFever to you!) from the Drummond-Barbosa lab will be presenting:
TGF-β and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance
Luo, Kleeman, Ashraf, Shaw, and Murphy
Cell, 2010, 143:299-312
A nice complement to the Oct. 19 journal club, and recently highlighted in the NYT as well!
Tuesday, October 26, 2010
Nov. 2, 2010 journal club
When and where:
Room E6519, Tuesday, Nov. 2, 12:15.
Jenn Wang from the Seydoux lab will be presenting:
Bucky ball organizes germ plasm assembly in zebrafish
Bontems, Stein, Marlow, Lyautey, Gupta, Mullins, and Dosch
Current Biology, 19:414-422
Jenn's comment on this paper selection:
"It's long been known that germ cell fate in many animals is specified by a specialized maternal cytoplasm, or germ plasm. However, the components of germ plasm and its assembly mechanisms are only recently beginning to be known. This paper shows that the Bucky ball protein is necessary for germ plasm assembly in zebrafish. Excitingly, they have some evidence that bucky ball may also be sufficient for germ cell formation. If I have time at the end, I will talk a little bit about our work on C. elegans germ granule partitioning, which has been thought to specify worm germ cells."
Room E6519, Tuesday, Nov. 2, 12:15.
Jenn Wang from the Seydoux lab will be presenting:
Bucky ball organizes germ plasm assembly in zebrafish
Bontems, Stein, Marlow, Lyautey, Gupta, Mullins, and Dosch
Current Biology, 19:414-422
Jenn's comment on this paper selection:
"It's long been known that germ cell fate in many animals is specified by a specialized maternal cytoplasm, or germ plasm. However, the components of germ plasm and its assembly mechanisms are only recently beginning to be known. This paper shows that the Bucky ball protein is necessary for germ plasm assembly in zebrafish. Excitingly, they have some evidence that bucky ball may also be sufficient for germ cell formation. If I have time at the end, I will talk a little bit about our work on C. elegans germ granule partitioning, which has been thought to specify worm germ cells."
Tuesday, October 12, 2010
Oct. 19, 2010 journal club
When and where:
Room E6519 (same as Sept. 21), Tuesday, Oct. 19, 12:15.
Lauren from the Evans lab will be presenting:
L. Lister, A. Kouznetsova, L. Hyslop, D. Kalleas, S. Pace, J. Barel, A. Nathan, V. Floros, C. Adelfalk and Y. Watanabe et al.,
Age-related meiotic segregation errors in mammalian oocytes are preceded by depletion of cohesin and Sgo2
Curr. Biol. 20 (2010), pp. 1511–1521.
... Ah, among the greatest stresses to many a female is the concept that "advanced maternal age" starts at 35. (I get numerous looks of disappointment as I lecture about this in my basic reproductive biology class, and note that it is indeed a biological reality of the way females do meiosis.) Here is Lauren's comments of why she picked this paper:
"It is well known that meiotic segregation errors are more common with increased maternal age, but surprisingly the molecular basis of these meiotic errors are not completely understood. As the trend for women to delay childbearing grows, it becomes critical to understand "what makes a good egg go bad" (this is part of the title of a recent review by Pat Hunt and Terry Hassold). The paper I chose explores the loss of chromosome cohesion as an important factor in age-related meiotic errors. While this is not directly related to my research, this paper helps to address a critical question in the field of reproductive biology that potentially has huge implications for human health."
Also, Hunt and Hassold did a commentary on the three papers on this topic that were published together in this issue of Current Biology:
Hunt and Hassold commentary
Renenkova et al., Curr. Biol. 20 (2010), pp. 1529–1533
Chiang et al., Curr. Biol. 20 (2010), pp. 1522–1528
Room E6519 (same as Sept. 21), Tuesday, Oct. 19, 12:15.
Lauren from the Evans lab will be presenting:
L. Lister, A. Kouznetsova, L. Hyslop, D. Kalleas, S. Pace, J. Barel, A. Nathan, V. Floros, C. Adelfalk and Y. Watanabe et al.,
Age-related meiotic segregation errors in mammalian oocytes are preceded by depletion of cohesin and Sgo2
Curr. Biol. 20 (2010), pp. 1511–1521.
... Ah, among the greatest stresses to many a female is the concept that "advanced maternal age" starts at 35. (I get numerous looks of disappointment as I lecture about this in my basic reproductive biology class, and note that it is indeed a biological reality of the way females do meiosis.) Here is Lauren's comments of why she picked this paper:
"It is well known that meiotic segregation errors are more common with increased maternal age, but surprisingly the molecular basis of these meiotic errors are not completely understood. As the trend for women to delay childbearing grows, it becomes critical to understand "what makes a good egg go bad" (this is part of the title of a recent review by Pat Hunt and Terry Hassold). The paper I chose explores the loss of chromosome cohesion as an important factor in age-related meiotic errors. While this is not directly related to my research, this paper helps to address a critical question in the field of reproductive biology that potentially has huge implications for human health."
Also, Hunt and Hassold did a commentary on the three papers on this topic that were published together in this issue of Current Biology:
Hunt and Hassold commentary
Renenkova et al., Curr. Biol. 20 (2010), pp. 1529–1533
Chiang et al., Curr. Biol. 20 (2010), pp. 1522–1528
Wednesday, September 29, 2010
Oct. 5, 2010 journal club
When and where:
Room E6519 (same as Sept. 21), Tuesday, Oct. 5, 12:15.
Elizabeth from the Drummond-Barbosa lab will be presenting:
Control of mammary stem cell function by steroid hormone signaling
Asselin-Labet et al.
Nature 465: 798-802
As Elizabeth notes, "It's not ovary or testes related, but there is more to 'reproductive biology' (at least in mammals) than just those two organs!" Indeed ... and I say double-bonus that this paper has stem cells and steroids in it.
FYI - Corresponding author Geoff Lindemann website
Room E6519 (same as Sept. 21), Tuesday, Oct. 5, 12:15.
Elizabeth from the Drummond-Barbosa lab will be presenting:
Control of mammary stem cell function by steroid hormone signaling
Asselin-Labet et al.
Nature 465: 798-802
As Elizabeth notes, "It's not ovary or testes related, but there is more to 'reproductive biology' (at least in mammals) than just those two organs!" Indeed ... and I say double-bonus that this paper has stem cells and steroids in it.
FYI - Corresponding author Geoff Lindemann website
Wednesday, September 22, 2010
Seminar of interest, Sept. 27, 2010
This coming Monday will be the Larry L. Ewing Lecture, and the speaker this year is Haifan Lin of Yale University, and the title of his talk is, "A novel small RNA-mediated epigenetic mechanism related to stem cells." (some pretty darn good keywords, huh!?) For those interested, here is a link to a semi-recent (2007) review on piRNAs and the proteins with which they interact; the seminar will present Haifan's latest findings.
Date: Sept. 27, 2010; 4:00 PM (to be followed by a reception)
Place: Sheldon Hall (Room W1214), Bloomberg School of Public Health
Should be a winner (not to mention a nice way to celebrate the life of Larry Ewing) ... please come!
Date: Sept. 27, 2010; 4:00 PM (to be followed by a reception)
Place: Sheldon Hall (Room W1214), Bloomberg School of Public Health
Should be a winner (not to mention a nice way to celebrate the life of Larry Ewing) ... please come!
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