Alas, we will be canceling the previously scheduled March 22 RBJC meeting.
But chin up! Do your own personal journal club!
There are a number of cool papers out there ... perhaps some inspiration for a paper pick for a future RBJC lies in this list of a few things that have been on my reading list:
Endocrine regulation of male fertility by the skeleton
Cell 144:796-809
Commentary
Insulin/FOXO signaling regulates ovarian prostaglandins critical for reproduction
Dev Cell 19:858
Most mouse spermatozoa begin their acrosome reaction before contact with the zona pellucida during in vitro fertilization
PNAS in press
Commentary 1
Commentary 2 [requires JHED sign-in]
MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline
Dev Cell 20:364-375
piRNA-associated germline nuage formation and spermatogenesis require MitoPLD profusogenic mitochondrial-surface lipid signaling
Dev Cell 20:376-387
Commentary
See you for our next meeting, April 12!
(We are skipping a week because a bunch of us will be away for the North American Testis Workshop and/or American Society of Andrology meeting)
Thursday, March 17, 2011
Thursday, March 3, 2011
March 8, 2011 journal club
When and where: Room W2303, 12:15, Tuesday March 8
Phylis from the Matunis lab will be presenting:
The mammalian Doublesex homolog DMRT1 is a transcriptional gatekeeper that controls the mitosis versus meiosis decision in male germ cells.
Dev Cell 19:612-624
Matson et al. [David Zarkower lab website]
Phylis admits that, "this publication is not related to my field of research. But I find it interesting because it sheds more light on the process that allows mammalian male germ cells to escape meiosis during development."
Agreed! This is a great topic, as the decision of when to stop doing mitosis and start doing meiosis is a fundamental difference between male and female germ cells -- and one of the earliest events of sexual dimorphism!
(And is it just me, or is the term "gatekeeper" being used a lot more to in descriptions of biological processes? Must be a Ghostbusters renaissance.)
Phylis from the Matunis lab will be presenting:
The mammalian Doublesex homolog DMRT1 is a transcriptional gatekeeper that controls the mitosis versus meiosis decision in male germ cells.
Dev Cell 19:612-624
Matson et al. [David Zarkower lab website]
Phylis admits that, "this publication is not related to my field of research. But I find it interesting because it sheds more light on the process that allows mammalian male germ cells to escape meiosis during development."
Agreed! This is a great topic, as the decision of when to stop doing mitosis and start doing meiosis is a fundamental difference between male and female germ cells -- and one of the earliest events of sexual dimorphism!
(And is it just me, or is the term "gatekeeper" being used a lot more to in descriptions of biological processes? Must be a Ghostbusters renaissance.)
Thursday, February 17, 2011
February 22, 2011 journal club
Where and when: Room E6519, Tuesday, 2/22, 12:15 PM
(and apologies up front - for the second RBJC in a row, I have an unavoidable and un-re-schedule-able conflict, and so won't be able to make it. Woe!)
Kate Laws of the Drummond-Barbosa lab will be presenting:
Brat promotes stem cell differentiaton via control of a bistable switch that restricts BMB signaling
Harris et al. [website for Hilary Ashe]
Dev Cell 20:72-83 (hot off the presses! - January 18, 2011)
... an interesting mix of biological studies and mathematical modeling, and obviously a topic near-and-dear to the hearts of Drummond-Barbosa lab members!
(and apologies up front - for the second RBJC in a row, I have an unavoidable and un-re-schedule-able conflict, and so won't be able to make it. Woe!)
Kate Laws of the Drummond-Barbosa lab will be presenting:
Brat promotes stem cell differentiaton via control of a bistable switch that restricts BMB signaling
Harris et al. [website for Hilary Ashe]
Dev Cell 20:72-83 (hot off the presses! - January 18, 2011)
... an interesting mix of biological studies and mathematical modeling, and obviously a topic near-and-dear to the hearts of Drummond-Barbosa lab members!
Friday, February 4, 2011
February 8, 2011 journal club
Where and when: Room W2303, Tuesday, 2/8, 12:15 PM
(and apologies up front - I will just be getting back from out of town and probably won't be able to make it)
Mandy Wilkinson of the Evans lab will be presenting two papers related to a certain step of fertilization, sperm interaction with the zona pellucida. (This is sort of a smackdown between genetic approaches and structural biology!)
Gamete recognition in mice depends on the cleavage status of an egg's zona pellucida protein
Science 329: 216-219
Gahlay et al. - from Jurrien Dean's group at NIDDK
Insights into egg coat assembly and sperm-egg interaction from the X-ray structure of full-length ZP3
Cell 143: 404-415
Han et al. - from Luca Jovine's group at the Karolinka Institute
Link to the structure
FYI - Perspectives articles related to these papers:
Mechanisms of sperm-egg interactions: Between sugars and broken bonds
Science Signaling 3:pe35
Egg's ZP3 structure speaks volumes
Cell 143: 337-338
(and apologies up front - I will just be getting back from out of town and probably won't be able to make it)
Mandy Wilkinson of the Evans lab will be presenting two papers related to a certain step of fertilization, sperm interaction with the zona pellucida. (This is sort of a smackdown between genetic approaches and structural biology!)
Gamete recognition in mice depends on the cleavage status of an egg's zona pellucida protein
Science 329: 216-219
Gahlay et al. - from Jurrien Dean's group at NIDDK
Insights into egg coat assembly and sperm-egg interaction from the X-ray structure of full-length ZP3
Cell 143: 404-415
Han et al. - from Luca Jovine's group at the Karolinka Institute
Link to the structure
FYI - Perspectives articles related to these papers:
Mechanisms of sperm-egg interactions: Between sugars and broken bonds
Science Signaling 3:pe35
Egg's ZP3 structure speaks volumes
Cell 143: 337-338
Wednesday, January 19, 2011
Jan. 25, 2011 journal club
Matt Beattie of the Zirkin lab helps us kick off our 2011 meetings (thanks, Matt!).
We'll meet at 12:15, Tuesday, Jan. 25, in Room E6519.
Matt will be presenting:
ROS inhibit the expression of testicular steroidogenic enzyme genes via the suppression of Nur77 transactivation.
Lee et al.
Free Radical Biology and Medicine, 2009, 47: 1591-1600
As Matt comments about this paper:
"I picked this paper because it is, well it's right in my field of study. This paper wants to establish a basis (via signalling and transcriptional regulation) for steroidogenic aging. While the "cause" of aging is still hotly debated, many groups are trying to establish an aging profile in both constantly dividing and terminally differentiated (or very low turnover) cells. The Leydig cell provides a great example of an aging terminally differentiated cell and allows us to study various aspects of the aging cell while measuring it's capacity to make steroids as a marker for their function."
We'll meet at 12:15, Tuesday, Jan. 25, in Room E6519.
Matt will be presenting:
ROS inhibit the expression of testicular steroidogenic enzyme genes via the suppression of Nur77 transactivation.
Lee et al.
Free Radical Biology and Medicine, 2009, 47: 1591-1600
As Matt comments about this paper:
"I picked this paper because it is, well it's right in my field of study. This paper wants to establish a basis (via signalling and transcriptional regulation) for steroidogenic aging. While the "cause" of aging is still hotly debated, many groups are trying to establish an aging profile in both constantly dividing and terminally differentiated (or very low turnover) cells. The Leydig cell provides a great example of an aging terminally differentiated cell and allows us to study various aspects of the aging cell while measuring it's capacity to make steroids as a marker for their function."
Wednesday, January 12, 2011
RBJC schedule for Spring 2011
Our meetings for January-May are below --
[roughly] every other Tuesday (with a few Tuesdays skipped, like for the BMB departmental retreat)
12:15-1:30 PM
2/8/11 - Mandy Wilkinson (Evans lab) - Room W2303
2/22/11 - Kate Laws (Drummond-Barbosa lab) - Room E6519
3/8/11 - Phylis Hetie (Matunis lab) - Room W2303
3/22/11 - Min-Young Kim (Drummond-Barbosa lab) - Room E6519
4/12/11 - Shiying Jin (Zirkin lab)- Room W2303
4/26/11 - Andrew Wolfe (Yay! A faculty member stepping up to present!) - Room E6519
5/17/11 - Dolly Singh (Wright lab) - Room E6519
[roughly] every other Tuesday (with a few Tuesdays skipped, like for the BMB departmental retreat)
12:15-1:30 PM
- Presenters - The room reservation starts at 12:00, so you can get in a little early for set-up.
- Everyone - Please note that we are in two different rooms (alas and once again, we couldn't get E6519 for all our meetings).
2/8/11 - Mandy Wilkinson (Evans lab) - Room W2303
2/22/11 - Kate Laws (Drummond-Barbosa lab) - Room E6519
3/8/11 - Phylis Hetie (Matunis lab) - Room W2303
3/22/11 - Min-Young Kim (Drummond-Barbosa lab) - Room E6519
4/12/11 - Shiying Jin (Zirkin lab)- Room W2303
4/26/11 - Andrew Wolfe (Yay! A faculty member stepping up to present!) - Room E6519
5/17/11 - Dolly Singh (Wright lab) - Room E6519
Wednesday, December 8, 2010
Dec. 14, 2010 journal club
When and where:
Room W2303, Tuesday, Nov. 30, 12:15.
Hyo from the Evans lab will be presenting:
Granulosa Cell Ligand NPPC and Its Receptor NPR2 Maintain Meiotic Arrest in Mouse Oocytes
Zhang M, Su YQ, Sugiura K, Xia G, Eppig JJ [Eppig Jax website]
Science, 2010, 330: 366-9
Hyo's comment on her paper choice:
"Mammalian oocytes are arrested at prophase I until signals allow for their meiotic maturation. This paper proposes a mechanism by which the arrest is maintained. The paper is especially interesting to me as I have observed differences in spindle morphology and cortical mechanics in mouse eggs matured in vivo vs. in vitro. If time permits, I will share some of my own findings!"
Room W2303, Tuesday, Nov. 30, 12:15.
Hyo from the Evans lab will be presenting:
Granulosa Cell Ligand NPPC and Its Receptor NPR2 Maintain Meiotic Arrest in Mouse Oocytes
Zhang M, Su YQ, Sugiura K, Xia G, Eppig JJ [Eppig Jax website]
Science, 2010, 330: 366-9
Hyo's comment on her paper choice:
"Mammalian oocytes are arrested at prophase I until signals allow for their meiotic maturation. This paper proposes a mechanism by which the arrest is maintained. The paper is especially interesting to me as I have observed differences in spindle morphology and cortical mechanics in mouse eggs matured in vivo vs. in vitro. If time permits, I will share some of my own findings!"
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