Where and when: Room E6519, Tuesday, 2/22, 12:15 PM
(and apologies up front - for the second RBJC in a row, I have an unavoidable and un-re-schedule-able conflict, and so won't be able to make it. Woe!)
Kate Laws of the Drummond-Barbosa lab will be presenting:
Brat promotes stem cell differentiaton via control of a bistable switch that restricts BMB signaling
Harris et al. [website for Hilary Ashe]
Dev Cell 20:72-83 (hot off the presses! - January 18, 2011)
... an interesting mix of biological studies and mathematical modeling, and obviously a topic near-and-dear to the hearts of Drummond-Barbosa lab members!
Thursday, February 17, 2011
Friday, February 4, 2011
February 8, 2011 journal club
Where and when: Room W2303, Tuesday, 2/8, 12:15 PM
(and apologies up front - I will just be getting back from out of town and probably won't be able to make it)
Mandy Wilkinson of the Evans lab will be presenting two papers related to a certain step of fertilization, sperm interaction with the zona pellucida. (This is sort of a smackdown between genetic approaches and structural biology!)
Gamete recognition in mice depends on the cleavage status of an egg's zona pellucida protein
Science 329: 216-219
Gahlay et al. - from Jurrien Dean's group at NIDDK
Insights into egg coat assembly and sperm-egg interaction from the X-ray structure of full-length ZP3
Cell 143: 404-415
Han et al. - from Luca Jovine's group at the Karolinka Institute
Link to the structure
FYI - Perspectives articles related to these papers:
Mechanisms of sperm-egg interactions: Between sugars and broken bonds
Science Signaling 3:pe35
Egg's ZP3 structure speaks volumes
Cell 143: 337-338
(and apologies up front - I will just be getting back from out of town and probably won't be able to make it)
Mandy Wilkinson of the Evans lab will be presenting two papers related to a certain step of fertilization, sperm interaction with the zona pellucida. (This is sort of a smackdown between genetic approaches and structural biology!)
Gamete recognition in mice depends on the cleavage status of an egg's zona pellucida protein
Science 329: 216-219
Gahlay et al. - from Jurrien Dean's group at NIDDK
Insights into egg coat assembly and sperm-egg interaction from the X-ray structure of full-length ZP3
Cell 143: 404-415
Han et al. - from Luca Jovine's group at the Karolinka Institute
Link to the structure
FYI - Perspectives articles related to these papers:
Mechanisms of sperm-egg interactions: Between sugars and broken bonds
Science Signaling 3:pe35
Egg's ZP3 structure speaks volumes
Cell 143: 337-338
Wednesday, January 19, 2011
Jan. 25, 2011 journal club
Matt Beattie of the Zirkin lab helps us kick off our 2011 meetings (thanks, Matt!).
We'll meet at 12:15, Tuesday, Jan. 25, in Room E6519.
Matt will be presenting:
ROS inhibit the expression of testicular steroidogenic enzyme genes via the suppression of Nur77 transactivation.
Lee et al.
Free Radical Biology and Medicine, 2009, 47: 1591-1600
As Matt comments about this paper:
"I picked this paper because it is, well it's right in my field of study. This paper wants to establish a basis (via signalling and transcriptional regulation) for steroidogenic aging. While the "cause" of aging is still hotly debated, many groups are trying to establish an aging profile in both constantly dividing and terminally differentiated (or very low turnover) cells. The Leydig cell provides a great example of an aging terminally differentiated cell and allows us to study various aspects of the aging cell while measuring it's capacity to make steroids as a marker for their function."
We'll meet at 12:15, Tuesday, Jan. 25, in Room E6519.
Matt will be presenting:
ROS inhibit the expression of testicular steroidogenic enzyme genes via the suppression of Nur77 transactivation.
Lee et al.
Free Radical Biology and Medicine, 2009, 47: 1591-1600
As Matt comments about this paper:
"I picked this paper because it is, well it's right in my field of study. This paper wants to establish a basis (via signalling and transcriptional regulation) for steroidogenic aging. While the "cause" of aging is still hotly debated, many groups are trying to establish an aging profile in both constantly dividing and terminally differentiated (or very low turnover) cells. The Leydig cell provides a great example of an aging terminally differentiated cell and allows us to study various aspects of the aging cell while measuring it's capacity to make steroids as a marker for their function."
Wednesday, January 12, 2011
RBJC schedule for Spring 2011
Our meetings for January-May are below --
[roughly] every other Tuesday (with a few Tuesdays skipped, like for the BMB departmental retreat)
12:15-1:30 PM
2/8/11 - Mandy Wilkinson (Evans lab) - Room W2303
2/22/11 - Kate Laws (Drummond-Barbosa lab) - Room E6519
3/8/11 - Phylis Hetie (Matunis lab) - Room W2303
3/22/11 - Min-Young Kim (Drummond-Barbosa lab) - Room E6519
4/12/11 - Shiying Jin (Zirkin lab)- Room W2303
4/26/11 - Andrew Wolfe (Yay! A faculty member stepping up to present!) - Room E6519
5/17/11 - Dolly Singh (Wright lab) - Room E6519
[roughly] every other Tuesday (with a few Tuesdays skipped, like for the BMB departmental retreat)
12:15-1:30 PM
- Presenters - The room reservation starts at 12:00, so you can get in a little early for set-up.
- Everyone - Please note that we are in two different rooms (alas and once again, we couldn't get E6519 for all our meetings).
2/8/11 - Mandy Wilkinson (Evans lab) - Room W2303
2/22/11 - Kate Laws (Drummond-Barbosa lab) - Room E6519
3/8/11 - Phylis Hetie (Matunis lab) - Room W2303
3/22/11 - Min-Young Kim (Drummond-Barbosa lab) - Room E6519
4/12/11 - Shiying Jin (Zirkin lab)- Room W2303
4/26/11 - Andrew Wolfe (Yay! A faculty member stepping up to present!) - Room E6519
5/17/11 - Dolly Singh (Wright lab) - Room E6519
Wednesday, December 8, 2010
Dec. 14, 2010 journal club
When and where:
Room W2303, Tuesday, Nov. 30, 12:15.
Hyo from the Evans lab will be presenting:
Granulosa Cell Ligand NPPC and Its Receptor NPR2 Maintain Meiotic Arrest in Mouse Oocytes
Zhang M, Su YQ, Sugiura K, Xia G, Eppig JJ [Eppig Jax website]
Science, 2010, 330: 366-9
Hyo's comment on her paper choice:
"Mammalian oocytes are arrested at prophase I until signals allow for their meiotic maturation. This paper proposes a mechanism by which the arrest is maintained. The paper is especially interesting to me as I have observed differences in spindle morphology and cortical mechanics in mouse eggs matured in vivo vs. in vitro. If time permits, I will share some of my own findings!"
Room W2303, Tuesday, Nov. 30, 12:15.
Hyo from the Evans lab will be presenting:
Granulosa Cell Ligand NPPC and Its Receptor NPR2 Maintain Meiotic Arrest in Mouse Oocytes
Zhang M, Su YQ, Sugiura K, Xia G, Eppig JJ [Eppig Jax website]
Science, 2010, 330: 366-9
Hyo's comment on her paper choice:
"Mammalian oocytes are arrested at prophase I until signals allow for their meiotic maturation. This paper proposes a mechanism by which the arrest is maintained. The paper is especially interesting to me as I have observed differences in spindle morphology and cortical mechanics in mouse eggs matured in vivo vs. in vitro. If time permits, I will share some of my own findings!"
Wednesday, November 24, 2010
Nov. 30, 2010 journal club
When and where:
Room E6519, Tuesday, Nov. 30, 12:15.
Rachel from the Matunis lab will be presenting:
Functional hierarchy and reversibility within the murine spermatogenic stem cell compartment
Nakagawa et al.
Science, 2010, 328:62-67
Rachel's comment on this paper:
"I picked this one because it beautifully illustrates that the mouse germline is not simply a linear path of cells that is fed by stem cells balancing self renewal and differentiation. Spermatogonia on their way down a path of differentiation can revert toward a more undifferentiated state to keep the germline in balance. Of course we already had hints of this from the awesome model system that is Drosophila but it is always reassuring to find that observations in model organisms hold true up the evolutionary ladder. Previously, in a paper that Becca did for RBJC, (Barroca et al.) it was shown that spermatogonia (no stem cells) could be transplanted into gamma irradiated mice with no functional germline niche, and the transplanted cells could reconstitute the niche. This suggested that these cells were capable of dedifferentiating but this paper is the first to make this observation in vivo in a wildtype (i.e., non-transplanted) situation."
Other papers that Rachel notes are of interest:
Spralding and Fan, "Counterfeiting the family jewels," Cell Stem Cell, 2010, 6:405-406.
Klein et al., "Mouse germ line stem cells undergo rapid and stochastic turnover," Cell Stem Cell, 2010, 7:214-224.
Room E6519, Tuesday, Nov. 30, 12:15.
Rachel from the Matunis lab will be presenting:
Functional hierarchy and reversibility within the murine spermatogenic stem cell compartment
Nakagawa et al.
Science, 2010, 328:62-67
Rachel's comment on this paper:
"I picked this one because it beautifully illustrates that the mouse germline is not simply a linear path of cells that is fed by stem cells balancing self renewal and differentiation. Spermatogonia on their way down a path of differentiation can revert toward a more undifferentiated state to keep the germline in balance. Of course we already had hints of this from the awesome model system that is Drosophila but it is always reassuring to find that observations in model organisms hold true up the evolutionary ladder. Previously, in a paper that Becca did for RBJC, (Barroca et al.) it was shown that spermatogonia (no stem cells) could be transplanted into gamma irradiated mice with no functional germline niche, and the transplanted cells could reconstitute the niche. This suggested that these cells were capable of dedifferentiating but this paper is the first to make this observation in vivo in a wildtype (i.e., non-transplanted) situation."
Other papers that Rachel notes are of interest:
Spralding and Fan, "Counterfeiting the family jewels," Cell Stem Cell, 2010, 6:405-406.
Klein et al., "Mouse germ line stem cells undergo rapid and stochastic turnover," Cell Stem Cell, 2010, 7:214-224.
Monday, November 1, 2010
Nov. 16, 2010 journal club
When and where:
Room W2303, Tuesday, Nov. 16, 12:15.
(Note the different room -- we got bumped from E6519 for this week, and will be in the room on the 2nd floor that we used most of last year.)
Newly-defended Leesa (that's DR. LaFever to you!) from the Drummond-Barbosa lab will be presenting:
TGF-β and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance
Luo, Kleeman, Ashraf, Shaw, and Murphy
Cell, 2010, 143:299-312
A nice complement to the Oct. 19 journal club, and recently highlighted in the NYT as well!
Room W2303, Tuesday, Nov. 16, 12:15.
(Note the different room -- we got bumped from E6519 for this week, and will be in the room on the 2nd floor that we used most of last year.)
Newly-defended Leesa (that's DR. LaFever to you!) from the Drummond-Barbosa lab will be presenting:
TGF-β and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance
Luo, Kleeman, Ashraf, Shaw, and Murphy
Cell, 2010, 143:299-312
A nice complement to the Oct. 19 journal club, and recently highlighted in the NYT as well!
Subscribe to:
Posts (Atom)