Friday, October 26, 2012

November 6, 2012 journal club

  • When:  Tuesday, Nov. 6, 12:15 PM  
  • Where:  Room W4019  
    • W4019 is a small classroom on the eastern side of the SPH building (couldn't get E6519 for all of our meetings)
Lauren Matthews (Evans lab) will be presenting:
 
MARF1 Regulates Essential Oogenic Processes in Mice
Su et al., Science (2012) 335:1496-1499
See also the feature on this paper in Biology of Reproduction's "World of Reproductive Biology"

Lauren's comments on her paper choice:

"This paper characterizes an interesting mutant from the Jackson Lab's Reproductive Genomics project.  Mutations in Marf1 (Meiotic arrest female 1) resulted in defects in oocyte meiotic maturation and female infertility.  I chose this paper because one of the defects seen in Marf1 mutant mice was the upregulation of protein phosphatase 2 catalytic subunit (PPP2CB).  Increased PP2 activity contributes to the meiotic maturation defect seen Marf1 mutant mice.  One of the goals of my thesis research project is to characterize a novel pathway regulating PP2A function in mouse oocytes, so I read this paper with great interest!"

Thursday, October 4, 2012

October 9, 2012 journal club

  • When:  Tuesday, Oct. 9, 12:15 PM  
  • Where:  Room W4019  
    • W4019 is a small classroom on the eastern side of the SPH building (Alas, we couldn't get E6519 for all of our meetings)
 Hyo Lee (an Evans lab member) will be presenting:  

DNA Damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa
Molecular Cell, EPub ahead of print (doi: 10.1016/j.molcel.2012.08.017)
Kerr et al.  [Andreas Strasser lab link]

This paper also was recently highlighted in the lay/science press (such as EurekAlert and ScienceDaily) as well as Biology of Reproduction's regular column, World of Reproductive Biology.  

Hyo's comment on this paper pick: 
    "I thought this article had an interesting combination of genome integrity and reproductive biology.  Preserving fertility in women cancer patients is becoming an increasingly important aspect of cancer treatment, and this paper provides insights into some biological aspects affecting fertility preservation.  In our lab, we have an expert in this field, Mindy Christianson, MD, a fellow in the Division of Reproductive Endocrinology and Infertility in the Department of Gynecology and Obstetrics, who can also share her clinical expertise on this subject during our discussions."

VoilĂ !  Another paper with broad relevance to the multiple interests in the RBJC group and BMB department!  As always, all welcome!