Wednesday, December 8, 2010

Dec. 14, 2010 journal club

When and where:
Room W2303, Tuesday, Nov. 30, 12:15.

Hyo from the Evans lab will be presenting:

Granulosa Cell Ligand NPPC and Its Receptor NPR2 Maintain Meiotic Arrest in Mouse Oocytes
Zhang M, Su YQ, Sugiura K, Xia G, Eppig JJ [Eppig Jax website]
Science, 2010, 330: 366-9

Hyo's comment on her paper choice:
"Mammalian oocytes are arrested at prophase I until signals allow for their meiotic maturation. This paper proposes a mechanism by which the arrest is maintained. The paper is especially interesting to me as I have observed differences in spindle morphology and cortical mechanics in mouse eggs matured in vivo vs. in vitro. If time permits, I will share some of my own findings!"