When and where:
Room E6519, Tuesday, Nov. 2, 12:15.
Jenn Wang from the Seydoux lab will be presenting:
Bucky ball organizes germ plasm assembly in zebrafish
Bontems, Stein, Marlow, Lyautey, Gupta, Mullins, and Dosch
Current Biology, 19:414-422
Jenn's comment on this paper selection:
"It's long been known that germ cell fate in many animals is specified by a specialized maternal cytoplasm, or germ plasm. However, the components of germ plasm and its assembly mechanisms are only recently beginning to be known. This paper shows that the Bucky ball protein is necessary for germ plasm assembly in zebrafish. Excitingly, they have some evidence that bucky ball may also be sufficient for germ cell formation. If I have time at the end, I will talk a little bit about our work on C. elegans germ granule partitioning, which has been thought to specify worm germ cells."
Tuesday, October 26, 2010
Tuesday, October 12, 2010
Oct. 19, 2010 journal club
When and where:
Room E6519 (same as Sept. 21), Tuesday, Oct. 19, 12:15.
Lauren from the Evans lab will be presenting:
L. Lister, A. Kouznetsova, L. Hyslop, D. Kalleas, S. Pace, J. Barel, A. Nathan, V. Floros, C. Adelfalk and Y. Watanabe et al.,
Age-related meiotic segregation errors in mammalian oocytes are preceded by depletion of cohesin and Sgo2
Curr. Biol. 20 (2010), pp. 1511–1521.
... Ah, among the greatest stresses to many a female is the concept that "advanced maternal age" starts at 35. (I get numerous looks of disappointment as I lecture about this in my basic reproductive biology class, and note that it is indeed a biological reality of the way females do meiosis.) Here is Lauren's comments of why she picked this paper:
"It is well known that meiotic segregation errors are more common with increased maternal age, but surprisingly the molecular basis of these meiotic errors are not completely understood. As the trend for women to delay childbearing grows, it becomes critical to understand "what makes a good egg go bad" (this is part of the title of a recent review by Pat Hunt and Terry Hassold). The paper I chose explores the loss of chromosome cohesion as an important factor in age-related meiotic errors. While this is not directly related to my research, this paper helps to address a critical question in the field of reproductive biology that potentially has huge implications for human health."
Also, Hunt and Hassold did a commentary on the three papers on this topic that were published together in this issue of Current Biology:
Hunt and Hassold commentary
Renenkova et al., Curr. Biol. 20 (2010), pp. 1529–1533
Chiang et al., Curr. Biol. 20 (2010), pp. 1522–1528
Room E6519 (same as Sept. 21), Tuesday, Oct. 19, 12:15.
Lauren from the Evans lab will be presenting:
L. Lister, A. Kouznetsova, L. Hyslop, D. Kalleas, S. Pace, J. Barel, A. Nathan, V. Floros, C. Adelfalk and Y. Watanabe et al.,
Age-related meiotic segregation errors in mammalian oocytes are preceded by depletion of cohesin and Sgo2
Curr. Biol. 20 (2010), pp. 1511–1521.
... Ah, among the greatest stresses to many a female is the concept that "advanced maternal age" starts at 35. (I get numerous looks of disappointment as I lecture about this in my basic reproductive biology class, and note that it is indeed a biological reality of the way females do meiosis.) Here is Lauren's comments of why she picked this paper:
"It is well known that meiotic segregation errors are more common with increased maternal age, but surprisingly the molecular basis of these meiotic errors are not completely understood. As the trend for women to delay childbearing grows, it becomes critical to understand "what makes a good egg go bad" (this is part of the title of a recent review by Pat Hunt and Terry Hassold). The paper I chose explores the loss of chromosome cohesion as an important factor in age-related meiotic errors. While this is not directly related to my research, this paper helps to address a critical question in the field of reproductive biology that potentially has huge implications for human health."
Also, Hunt and Hassold did a commentary on the three papers on this topic that were published together in this issue of Current Biology:
Hunt and Hassold commentary
Renenkova et al., Curr. Biol. 20 (2010), pp. 1529–1533
Chiang et al., Curr. Biol. 20 (2010), pp. 1522–1528
Subscribe to:
Posts (Atom)